Zélia Silva

Interesses Científicos

The Glycoimmunology research lab employs unique molecular and biological methods combined with patient-centric approaches to disentangle biological mechanisms modulated by glycosylation and novel glycan-based therapies. Our particular focus has been on sialylated glycans that affect the function of relevant cell surface molecules. We developed technologies to alter sialic acid contents and a multi-modular platform for high-throughput development of anti-glycan antibodies, with potential clinical application. We collaborate extensively with pharmaceuticals and patient associations to translate into therapies for cancer and congenital disorders of glycosylation (CDG). The Glycoimmunology research lab employs unique molecular and biological methods combined with patient-centric approaches to disentangle biological mechanisms modulated by glycosylation and novel glycan-based therapies. https://www.ucibio.pt/research-groups/lab/glycoimmunology Keywords: Glycoimmunology, Dendritic cells, antigen-presentation, immunomodulation, cancer, congenital disorders of glycosylation

Publicações Representativas

Silva, Zélia; Ferro, Tiago; Almeida, Danielle; Soares, Helena; Ferreira, JoséAlexandre; Deschepper, Fanny M.; Hensbergen, Paul J.; et al. "MHC Class IStability is Modulated by Cell Surface Sialylation in Human Dendritic Cells".Pharmaceutics 12 3 (2020): 249. http://dx.doi.org/10.3390/pharmaceutics12030249.

Ferreira, Inês; Carrascal, Myl¿ne; Mineiro, A.; Bugalho, António; Borralho, Paula;Silva, Zélia; Dall'olio, Fabio; Videira, Paula. "Carcinoembryonic antigen is a sialylLewis x/a carrier and an E-selectin ligand in non-small cell lung cancer".International Journal of Oncology (2019): http://dx.doi.org/10.3892/ijo.2019.4886.10.3892/ijo.2019.48863

Marques, G, Silva, Zélia and Videira, Paula "Antitumor Efficacy of Human Monocyte-Derived Dendritic Cells: Comparing Effects of two Monocyte Isolation Methods". Journal: BiologicalProcedures Online (2018): https://biologicalproceduresonline.biomedcentral.com/articles/10.1186/s12575-018-0069-6.10.1186/s12575-018-0069-64

Guadalupe Cabral, M.; Pereira, M.; Silva, Z.; Iria, I.; Coutinho, C.; Lopes, A.; Sá-Correia, I.; Videira, P.A.. "Using dendritic cells to evaluate how Burkholderiacenocepacia clonal isolates from a chronically infected cystic fibrosis patient subvert immune functions". Medical Microbiology and Immunology 206 2(2017): 111-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006342004&partnerID=MN8TOARS.10.1007/s00430-016-0488-48

Silva M; Silva Z*; Marques G; Ferro T; Gonçalves M; Monteiro M; van Vliet SJ; et al."Sialic acid removal from dendritic cells improves antigen cross-presentationand boosts anti-tumor immune responses.". (2016): http://europepmc.org/abstract/med/27203391.10.18632/oncotarget.94199

*co-first