20-01-2025
A collaborative research study in the framework of the European project GLYCOTwinning, led by researchers from UCIBIO-NOVA FCT and CIC BioGUNE revealed, for the first time, the molecular mechanism behind the binding of a specific antibody to a glycan-based antigen commonly found on malignant cells of some of the most difficult cancers to treat. The study was coordinated by Filipa Marcelo from (Bio)molecular Structure and Interactions by NMR Lab at UCIBIO-NOVA FCT and June Ereño-Orbea from CIC bioGUNE with important contribution of Paula Videira from Glycoimmunology Lab and Angelina Palma from GlycoLab at UCIBIO-NOVA, and the results were published recently in the Journal of American Chemical Society Au: “Decoding the Molecular Basis of the Specificity of an anti-sTn Antibody”.
this study provides, for the first time, the high-resolution information of sTn-antigen molecular recognition by an antibody. Key interactions between the sTn-antigen and the L2A5 antibody were unveiled, which might contribute to its selective targeting against tumour cells.
Decoding the Molecular Basis of the Specificity of an Anti-sTn Antibody
JACS Au 2024
Cátia O. Soares, Maria Elena Laugieri, Ana Sofia Grosso, Mariangela Natale, Helena Coelho, Sandra Behren, Jin Yu, Hui Cai, Antonio Franconetti, Iker Oyenarte, Maria Magnasco, Ana Gimeno, Nuno Ramos, Wengang Chai, Francisco Corzana, Ulrika Westerlind, Jesús Jiménez-Barbero, Angelina S. Palma, Paula A. Videira, June Ereño-Orbea, and Filipa Marcelo
DOI: 10.1021/jacsau.4c00921
